A machine learning model—specifically a random forest using amino acid and dipeptide features—was developed to predict anticancer activity in 10,000 antimicrobial peptides (AMPs). The model showed 79.5% accuracy on its validation set, and 1648 peptides demonstrated favorable anticancer properties. Additional analyses included clustering, physicochemical property predictions, and 3D homology modelling. These findings suggest potential dual effects of AMPs in cancer therapy.
@article{ozgen2024anticancer,title={In Silico Investigation of Anticancer Properties of Antimicrobial Peptides},author={Özgen, Ahmet Ozan},year={2024},publisher={Council of Higher Education,},}
2023
Enzymatic Targets for Drug Discovery Against Alzheimer’s Disease
Ahmet Ozan Özgen
In Drug Discovery for Alzheimer’s Disease: Recent Advances, 2023
Alzheimer’s Disease (AD) is a neurodegenerative disease. The disease itself is progressive and full recovery from it isn’t achievable yet. There are several hypotheses asserted (Cholinergic hypothesis, Amyloid hypothesis etc.) to explain the mechanisms behind the disease. Also, many targets have been identified for possible therapeutics and from these targets, numerous drug candidates have been evaluated in clinical trials. Unfortunately, most of these trials failed due to the enigmatic nature of this disease. Currently, there are 7103 targets associated with Alzheimer’s disease listed in the Open Targets platform where 1240 of them are enzyme-related. In this chapter, enzymatic targets of the AD have been reviewed, and those claimed to have disease modifying effects were selected and presented according to their clinical significance.
@incollection{ozgen2023enzymatic,title={Enzymatic Targets for Drug Discovery Against Alzheimer's Disease},author={Özgen, Ahmet Ozan},booktitle={Drug Discovery for Alzheimer's Disease: Recent Advances},publisher={Bentham Science,},year={2023},url={https://doi.org/10.2174/9789815136142123010009},doi={10.2174/9789815136142123010009},}
Pharmacokinetic Profile and a Bioequivalence Study of Apixaban in Healthy Volunteers
A single-dose, open-label, randomized, two-period cross-over study in 32 healthy male volunteers assessed bioequivalence between a test Apixaban tablet (Nobel İlaç) and the reference product (Eliquis 5 mg). Key pharmacokinetic parameters (Cmax, AUC) were within the CI 80-125%, indicating bioequivalence. No significant adverse events were observed, and the results confirm individual interchangeability of the test and reference products, supporting the test product’s use as a valid anticoagulant therapy option.
@article{ozgen2023pharmacokinetic,title={Pharmacokinetic Profile and a Bioequivalence Study of Apixaban in Healthy Volunteers},author={Özgen, Ahmet Ozan and others},journal={Nobel Medicus},publisher={Nobel Medicus,},year={2023},url={https://www.nobelmedicus.com/en/article/777},}
2022
Models of Spike, Envelope and Membrane Proteins of SARS-CoV-2 Variants for Possible Therapeutics
A study examined five SARS-CoV-2 variants of concern (VoC) by analyzing mutations in the spike, envelope, and membrane proteins. Most mutations were found in the spike protein; the envelope and membrane proteins had only one mutation each in some variants. These findings suggest that targeting the less mutated structural proteins could be useful for future vaccine and drug development.
@article{ozgen2022models,title={Models of Spike, Envelope and Membrane Proteins of SARS-CoV-2 Variants for Possible Therapeutics},author={Özgen, Ahmet Ozan and others},journal={Journal of Medical Topics and Updates},publisher={Journal of Medical Topics and Updates,},year={2022},url={https://doi.org/10.5281/zenodo.7476169},doi={10.5281/zenodo.7476169},}
2020
Antibiotic Susceptibility of Klebsiella pneumoniae Strains Isolated from Clinical Samples
Ahmet Ozan Özgen, and others
Journal of the Turkish Chemical Society Section A: Chemistry, 2020
A retrospective study analyzed 502 Klebsiella pneumoniae strains, revealing rising carbapenem resistance. K. pneumoniae, though part of normal human flora, causes nosocomial infections. Findings suggest escalating resistance, especially in critical care settings, prompting recommendation for stricter antibiotic management policies.
@article{ozgen2020antibiotic,title={Antibiotic Susceptibility of Klebsiella pneumoniae Strains Isolated from Clinical Samples},author={Özgen, Ahmet Ozan and others},journal={Journal of the Turkish Chemical Society Section A: Chemistry},publisher={Journal of the Turkish Chemical Society Section A: Chemistry,},year={2020},url={https://doi.org/10.18596/jotcsa.635088},doi={10.18596/jotcsa.635088},}